Gene Expression Literature Summary

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Bmp4  bone morphogenetic protein 4   (Synonyms: Bmp2b, Bmp2b1, Bmp2b-1, Bmp-4)
Results	Reference
1	J:44411 Aberg T, Wozney J, Thesleff I, Expression patterns of bone morphogenetic proteins (Bmps) in the developing mouse tooth suggest roles in morphogenesis and cell differentiation. Dev Dyn. 1997 Dec;210(4):383-96
1*	J:38383 Bellusci S, Furuta Y, Rush MG, Henderson R, Winnier G, Hogan BL, Involvement of Sonic hedgehog (Shh) in mouse embryonic lung growth and morphogenesis. Development. 1997 Jan;124(1):53-63
1	J:103829 Chen B, Schaevitz LR, McConnell SK, Fezl regulates the differentiation and axon targeting of layer 5 subcortical projection neurons in cerebral cortex. Proc Natl Acad Sci U S A. 2005 Nov 22;102(47):17184-9
1	J:153554 Chen J, Lan Y, Baek JA, Gao Y, Jiang R, Wnt/beta-catenin signaling plays an essential role in activation of odontogenic mesenchyme during early tooth development. Dev Biol. 2009 Oct 1;334(1):174-85
1	J:261197 Chen J, Van Gulden S, McGuire TL, Fleming AC, Oka C, Kessler JA, Peng CY, BMP-Responsive Protease HtrA1 Is Differentially Expressed in Astrocytes and Regulates Astrocytic Development and Injury Response. J Neurosci. 2018 Apr 11;38(15):3840-3857
1	J:180843 Davis N, Mor E, Ashery-Padan R, Roles for Dicer1 in the patterning and differentiation of the optic cup neuroepithelium. Development. 2011 Jan;138(1):127-38
1*	J:57104 Everett LA, Morsli H, Wu DK, Green ED, Expression pattern of the mouse ortholog of the Pendred's syndrome gene (Pds) suggests a key role for pendrin in the inner ear. Proc Natl Acad Sci U S A. 1999 Aug 17;96(17):9727-32
1	J:129765 Goulley J, Dahl U, Baeza N, Mishina Y, Edlund H, BMP4-BMPR1A signaling in beta cells is required for and augments glucose-stimulated insulin secretion. Cell Metab. 2007 Mar;5(3):207-19
1	J:80081 Gritli-Linde A, Bei M, Maas R, Zhang XM, Linde A, McMahon AP, Shh signaling within the dental epithelium is necessary for cell proliferation, growth and polarization. Development. 2002 Dec;129(23):5323-37
1	J:117334 Gritli-Linde A, Hallberg K, Harfe BD, Reyahi A, Kannius-Janson M, Nilsson J, Cobourne MT, Sharpe PT, McMahon AP, Linde A, Abnormal hair development and apparent follicular transformation to mammary gland in the absence of hedgehog signaling. Dev Cell. 2007 Jan;12(1):99-112
1*	J:171409 GUDMAP Consortium, GUDMAP: the GenitoUrinary Development Molecular Anatomy Project. www.gudmap.org. 2004;
1	J:86043 Han M, Yang X, Farrington JE, Muneoka K, Digit regeneration is regulated by Msx1 and BMP4 in fetal mice. Development. 2003 Nov;130(21):5123-32
1	J:217375 Heavner WE, Andoniadou CL, Pevny LH, Establishment of the neurogenic boundary of the mouse retina requires cooperation of SOX2 and WNT signaling. Neural Dev. 2014;9:27
1	J:256095 Huang WC, Ferris E, Cheng T, Horndli CS, Gleason K, Tamminga C, Wagner JD, Boucher KM, Christian JL, Gregg C, Diverse Non-genetic, Allele-Specific Expression Effects Shape Genetic Architecture at the Cellular Level in the Mammalian Brain. Neuron. 2017 Mar 8;93(5):1094-1109.e7
1*	J:69463 Huelsken J, Vogel R, Erdmann B, Cotsarelis G, Birchmeier W, beta-Catenin controls hair follicle morphogenesis and stem cell differentiation in the skin. Cell. 2001 May 18;105(4):533-45
1	J:242713 Ikeda Y, Zabbarova I, Schaefer CM, Bushnell D, De Groat WC, Kanai A, Bates CM, Fgfr2 is integral for bladder mesenchyme patterning and function. Am J Physiol Renal Physiol. 2017 Apr 01;312(4):F607-F618
1	J:260962 Kamiunten T, Ideno H, Shimada A, Arai Y, Terashima T, Tomooka Y, Nakamura Y, Nakashima K, Kimura H, Shinkai Y, Tachibana M, Nifuji A, Essential roles of G9a in cell proliferation and differentiation during tooth development. Exp Cell Res. 2017 Aug 15;357(2):202-210
1*	J:116785 Kettunen P, Nie X, Kvinnsland IH, Luukko K, Histological development and dynamic expression of Bmp2-6 mRNAs in the embryonic and postnatal mouse cranial base. Anat Rec A Discov Mol Cell Evol Biol. 2006 Dec;288(12):1250-8
1	J:47321 Kim HJ, Rice DP, Kettunen PJ, Thesleff I, FGF-, BMP- and Shh-mediated signalling pathways in the regulation of cranial suture morphogenesis and calvarial bone development. Development. 1998 Apr;125(7):1241-51
1	J:308704 Kiyokawa H, Yamaoka A, Matsuoka C, Tokuhara T, Abe T, Morimoto M, Airway basal stem cells reutilize the embryonic proliferation regulator, Tgfbeta-Id2 axis, for tissue regeneration. Dev Cell. 2021 Jul 12;56(13):1917-1929.e9
1	J:69382 Lamm ML, Podlasek CA, Barnett DH, Lee J, Clemens JQ, Hebner CM, Bushman W, Mesenchymal factor bone morphogenetic protein 4 restricts ductal budding and branching morphogenesis in the developing prostate. Dev Biol. 2001 Apr 15;232(2):301-14
1	J:82686 Liu J, Wilson S, Reh T, BMP receptor 1b is required for axon guidance and cell survival in the developing retina. Dev Biol. 2003 Apr 1;256(1):34-48
1*	J:82110 Luukko K, Loes S, Furmanek T, Fjeld K, Kvinnsland IH, Kettunen P, Identification of a novel putative signaling center, the tertiary enamel knot in the postnatal mouse molar tooth. Mech Dev. 2003 Mar;120(3):270-6
1*	J:162220 Magdaleno S, Jensen P, Brumwell CL, Seal A, Lehman K, Asbury A, Cheung T, Cornelius T, Batten DM, Eden C, Norland SM, Rice DS, Dosooye N, Shakya S, Mehta P, Curran T, BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. PLoS Biol. 2006 Apr;4(4):e86
1	J:85609 Merves M, Krane CM, Dou H, Greinwald JH, Menon AG, Choo D, Expression of aquaporin 1 and 5 in the developing mouse inner ear and audiovestibular assessment of an Aqp5 null mutant. J Assoc Res Otolaryngol. 2003 Jun;4(2):264-75
1*	J:47261 Morsli H, Choo D, Ryan A, Johnson R, Wu DK, Development of the mouse inner ear and origin of its sensory organs. J Neurosci. 1998 May 1;18(9):3327-35
1	J:309378 Naveau A, Zhang B, Meng B, Sutherland MT, Prochazkova M, Wen T, Marangoni P, Jones KB, Cox TC, Ganss B, Jheon AH, Klein OD, Isl1 Controls Patterning and Mineralization of Enamel in the Continuously Renewing Mouse Incisor. J Bone Miner Res. 2017 Nov;32(11):2219-2231
1	J:102993 Nie X, Apoptosis, proliferation and gene expression patterns in mouse developing tongue. Anat Embryol (Berl). 2005 Sep;210(2):125-32
1	J:135340 Nyeng P, Norgaard GA, Kobberup S, Jensen J, FGF10 maintains distal lung bud epithelium and excessive signaling leads to progenitor state arrest, distalization, and goblet cell metaplasia. BMC Dev Biol. 2008;8:2
1	J:90053 Ohazama A, Hu Y, Schmidt-Ullrich R, Cao Y, Scheidereit C, Karin M, Sharpe PT, A dual role for Ikk alpha in tooth development. Dev Cell. 2004 Feb;6(2):219-27
1	J:78541 Peretto P, Cummings D, Modena C, Behrens M, Venkatraman G, Fasolo A, Margolis FL, BMP mRNA and protein expression in the developing mouse olfactory system. J Comp Neurol. 2002 Sep 23;451(3):267-78
1*	J:35807 Phippard DJ, Weber-Hall SJ, Sharpe PT, Naylor MS, Jayatalake H, Maas R, Woo I, Roberts-Clark D, Francis-West PH, Liu YH, Maxson R, Hill RE, Dale TC, Regulation of Msx-1, Msx-2, Bmp-2 and Bmp-4 during foetal and postnatal mammary gland development. Development. 1996 Sep;122(9):2729-37
1	J:282858 Ramachandran J, Liu Z, Gray RS, Vokes SA, PRMT5 is necessary to form distinct cartilage identities in the knee and long bone. Dev Biol. 2019 Dec 15;456(2):154-163
1*	J:219823 Rosin JM, McAllister BB, Dyck RH, Percival CJ, Kurrasch DM, Cobb J, Mice lacking the transcription factor SHOX2 display impaired cerebellar development and deficits in motor coordination. Dev Biol. 2015 Mar 1;399(1):54-67
1	J:302551 Schlesinger SY, Seo S, Pryce BA, Tufa SF, Keene DR, Huang AH, Schweitzer R, Loss of Smad4 in the scleraxis cell lineage results in postnatal joint contracture. Dev Biol. 2021 Feb;470:108-120
1	J:83949 Sharov AA, Weiner L, Sharova TY, Siebenhaar F, Atoyan R, Reginato AM, McNamara CA, Funa K, Gilchrest BA, Brissette JL, Botchkarev VA, Noggin overexpression inhibits eyelid opening by altering epidermal apoptosis and differentiation. EMBO J. 2003 Jun 16;22(12):2992-3003
1	J:65598 Shou J, Murray RC, Rim PC, Calof AL, Opposing effects of bone morphogenetic proteins on neuron production and survival in the olfactory receptor neuron lineage. Development. 2000 Dec;127(24):5403-13
1	J:194442 Shu B, Zhang M, Xie R, Wang M, Jin H, Hou W, Tang D, Harris SE, Mishina Y, O'Keefe RJ, Hilton MJ, Wang Y, Chen D, BMP2, but not BMP4, is crucial for chondrocyte proliferation and maturation during endochondral bone development. J Cell Sci. 2011 Oct 15;124(Pt 20):3428-40
1	J:34295 Takemura T, Sakagami M, Takebayashi K, Umemoto M, Nakase T, Takaoka K, Kubo T, Kitamura Y, Nomura S, Localization of bone morphogenetic protein-4 messenger RNA in developing mouse cochlea. Hear Res. 1996 May;95(1-2):26-32
1	J:41137 Thesleff I, Aberg T, Tooth morphogenesis and the differentiation of ameloblasts. Ciba Found Symp. 1997;205:3-12; discussion 12-7
1*	J:215487 Thompson CL, Ng L, Menon V, Martinez S, Lee CK, Glattfelder K, Sunkin SM, Henry A, Lau C, Dang C, Garcia-Lopez R, Martinez-Ferre A, Pombero A, Rubenstein JL, Wakeman WB, Hohmann J, Dee N, Sodt AJ, Young R, Smith K, Nguyen TN, Kidney J, Kuan L, Jeromin A,Kaykas A, Miller J, Page D, Orta G, Bernard A, Riley Z, Smith S, Wohnoutka P, Hawrylycz MJ, Puelles L, Jones AR, A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain. Neuron. 2014 Jul 16;83(2):309-23
1*	J:67747 Thut CJ, Rountree RB, Hwa M, Kingsley DM, A large-scale in situ screen provides molecular evidence for the induction of eye anterior segment structures by the developing lens. Dev Biol. 2001 Mar 1;231(1):63-76
1	J:149923 Ueda H, Miyazaki Y, Matsusaka T, Utsunomiya Y, Kawamura T, Hosoya T, Ichikawa I, Bmp in podocytes is essential for normal glomerular capillary formation. J Am Soc Nephrol. 2008 Apr;19(4):685-94
1	J:31907 Vainio S, Karavanova I, Jowett A, Thesleff I, Identification of BMP-4 as a signal mediating secondary induction between epithelial and mesenchymal tissues during early tooth development. Cell. 1993 Oct 8;75(1):45-58
1	J:91704 Wang XP, Suomalainen M, Jorgez CJ, Matzuk MM, Wankell M, Werner S, Thesleff I, Modulation of activin/bone morphogenetic protein signaling by follistatin is required for the morphogenesis of mouse molar teeth. Dev Dyn. 2004 Sep;231(1):98-108
1	J:343328 Xie Z, Ma XH, Bai QF, Tang J, Sun JH, Jiang F, Guo W, Wang CM, Yang R, Wen YC, Wang FY, Chen YX, Zhang H, He DZ, Kelley MW, Yang S, Zhang WJ, ZBTB20 is essential for cochlear maturation and hearing in mice. Proc Natl Acad Sci U S A. 2023 Jun 13;120(24):e2220867120
1*	J:79481 Yu J, Carroll TJ, McMahon AP, Sonic hedgehog regulates proliferation and differentiation of mesenchymal cells in the mouse metanephric kidney. Development. 2002 Nov;129(22):5301-12
1	J:141138 Zhang Y, Burgess D, Overbeek PA, Govindarajan V, Dominant inhibition of lens placode formation in mice. Dev Biol. 2008 Nov 1;323(1):53-63